Effects of Saturated Fat From Meat and Cheese on Blood Lipids

Blood Lipids

Heart disease is the leading cause of death in many countries, and high saturated fat intake has long been thought to be a major risk factor.

For this reason, health authorities have recommended limiting the intake of foods rich in saturated fat, such as meat and high-fat cheese.

However, studies indicate that high-fat cheese may actually protect against heart disease.

Additionally, several recent meta-analyses have been unable to find a link between saturated fat consumption and heart disease. However, there may be a small reduction in cardiovascular “events” when replaced with polyunsaturated fat.

Blood Lipids

Study Reviewed

This randomized crossover trial examined how saturated fat from meat and cheese affected blood lipids.

Thorning et al. Diets With High-Fat Cheese, High-Fat Meat, or Carbohydrate on Cardiovascular Risk Markers in Overweight Postmenopausal Women: A Randomized Crossover Trial. American Journal of Clinical Nutrition 2015.


This study compared the effects of saturated animal fats and carbohydrates on blood lipids, apolipoproteins and fat digestibility.

Study Design

This 10-week study was a randomized crossover trial. A total of 19 postmenopausal women were recruited to participate.

Each participant’s energy requirements were calculated. Based on that, they were placed on a weight-maintenance diet to prevent weight changes during the study period.

The participants were then randomly assigned to one of three diets, each of which lasted for two weeks.

  1. High-cheese diet: This diet focused on cheese, but no other dairy products were included.
  2. High-meat diet: Participants on this diet were fed beef and pork, but no dairy products.
  3. Control diet: The control diet contained high amounts of carbs and low amounts of fat, as well as protein from lean meat. The carbs mainly consisted of fruit, white bread, pasta, marmalade, rice, cakes, biscuits and chocolate.

These three groups were isocaloric, meaning they had an equal energy content. In the high-cheese and high-meat groups, the percentage of energy provided was:

  • Protein: 15%.
  • Fat: 35% (13% from saturated fat).
  • Carbs: 50%.

In the control diet, the percentage of energy provided was approximately:

  • Protein: 15%.
  • Fat: 25%.
  • Carbs: 60%.

All three diets contained similar amounts of protein. The only difference was the source of fat — from cheese or meat — and the amount of fat, which differed between the high-fat/high-meat diets and the control diet.

Since this was a crossover trial, all participants received each of the test foods at different points during the study. However, the order in which they got the foods was randomized.

Additionally, due to the nature of the diets, it was impossible to blind the participants.

Each of the study cycles was separated by a 2-week period, to stabilize blood lipids between diets.

At the beginning and end of each study period, blood samples were taken after a 12-hour fast. Fat digestibility was estimated by measuring fat in stools.


A total of 5 participants dropped out during the study period, and 14 completed it.

Compared to the control diet, both the high-cheese and high-meat diets increased levels of the “good” HDL-cholesterol by 5% and 8%, respectively.

Apolipoprotein A-1 levels also increased by 8% and 4%, respectively. Apolipoprotein A-1 is the protein that carries HDL cholesterol in the blood, and having higher levels is a good thing.

In the high-cheese diet, the ratio of apolipoprotein B and apolipoprotein A-1 also went down by 5%, which indicates reduced heart disease risk.

Total cholesterol, LDL cholesterol, apolipoprotein B and triglycerides remained similar between groups.

Additionally, the fat in cheese did not seem to be efficiently absorbed.

Main Conclusions

The saturated fat in meat and cheese did not have adverse effects on blood lipids, compared to a high-carb, low-fat diet.

The study also found that some of the fat in cheese is not digested, and passes out of the body with feces.


This study was well-designed and does not have any apparent shortcomings.

However, it has several limitations.

  1. There were only 14 participants that completed the study.
  2. The duration of the study was short.
  3. The participant group was very specific — postmenopausal women.
  4. Macronutrients were closely matched between diets, so the study does not provide a direct comparison of either cheese or meat as a whole.
  5. There was not a direct comparison of the different saturated fats found in cheese and meat. However, isolating these fats would neglect the potential interaction of the different nutrients in whole foods.

What Do Other Studies Say?

A high-fat diet rich in dairy calcium significantly decreased LDL-cholesterol, compared to a low-calcium diet.

Contrasting the results of the current study, other studies have shown a reduction in HDL-cholesterol and apolipoprotein A-1 when saturated fat has been replaced with carbs.

Supporting the results, a few observational studies have found a positive association between cheese intake and levels of HDL-cholesterol and apo A-1.

Summary and Real Life Application

For some time, health authorities have been recommending low-fat diets, saying that saturated fat increases the risk of heart disease.

However, the findings of this study (and many others) contradict those sources.

At the end of the day, saturated fat isn’t the demon it has been made out to be.

There is no reason to avoid saturated fat from whole foods, but there is no reason to glorify it and eat much of it either. It is neither good or bad, just neutral.

Written by Aline Pilani

Hey, I’m Aline Pilani. I am a certified personal trainer and nutritionist. I have spent the last 10 years of my life helping people losing weight, increase their health and confidence, and I truly want to do the same for you.