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Past Week in Nutrition Science (Nov 6th–Nov 13th)

Past Week in Nutrition Science: This is an overview of interesting studies published on nutrition from Friday, Nov 6th, to Friday, Nov 13th.

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Past Week in Nutrition Science (Nov 6th–Nov 13th)

Research Reviews

We reviewed two articles this week: a research summary, published in The Lancet Oncology, and a research paper, from the American Journal of Clinical Nutrition.

Monday

Link: Do Red Meat and Processed Meat Really Cause Cancer?

Study: Carcinogenicity of consumption of red and processed meat.

Summary: The International Agency for Research on Cancer released a research summary on the effects of red meat and processed meat on cancer risk. The full results will be published in the IARC Monographs at a later date.

According to the paper, there is sufficient evidence linking a high intake of processed meat with an increased risk of colon cancer. Conversely, there is limited evidence that red meat causes cancer.

Wednesday

Link: Water vs Diet Soda: Which is Better for Weight Loss?

Study: Effects on weight loss in adults of replacing diet beverages with water during a hypoenergetic diet: a randomized, 24-wk clinical trial.

Summary: This randomized weight loss trial compared the effectiveness of diet soda and water in obese and overweight women.

The main finding was that drinking pure water promotes significantly greater weight loss, compared to diet soda. However, other studies have shown different results.

New Research From Around the World

Lots of new research was published this week. Some of the papers may be more than a week old, as we are constantly updating the list of journals we follow.

Below is a selection of the most interesting papers, organized by subject.

Obesity and Weight Loss

Association between eating rate and obesity: a systematic review and meta-analysis.

This meta-analysis combined the results of 23 observational studies examining whether eating food quickly is associated with obesity.

Not surprisingly, eating quickly turned out to be associated with excess body weight. These results support the idea that mindful eating may help with weight loss.


Caffeine intake is related to successful weight loss maintenance.

This observational study suggests that drinking caffeinated beverages, such as coffee, may help people maintain a healthy weight.


Cluster analysis of behavioural weight management strategies and associations with weight change in young women: a longitudinal analysis.

This cluster analysis roughly categorized the different weight loss strategies used by the 8,125 women in the the Australian Longitudinal Study of Women’s Health.

The most common weight loss strategies turned out to be dieting, eating less and exercising. Healthy eating and exercising were the most effective methods.


Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men.

This 1-year, weight-loss trial in men with central obesity showed that circulating vitamin D levels increased gradually with weight loss.

In fact, vitamin D levels increased by 26%, while visceral fat decreased by the same percentage.


Prebiotic consumption and the incidence of overweight in a Mediterranean cohort: the Seguimiento Universidad de Navarra Project.

Prebiotics are dietary substances, such as fiber and non-digestible carbs, that feed the beneficial bacteria in our digestive system. Scientists have suggested that consuming prebiotics may protect against weight gain or obesity.

This prospective, observational study in middle-aged, normal-weight adults found that those who consumed high amounts of prebiotics, such as fructans and galacto-oligosaccharides, were less likely to be overweight.


In overweight and obese women, dietary iron absorption is reduced and the enhancement of iron absorption by ascorbic acid is one-half that in normal-weight women.

Iron deficiency is a common problem in both overweight and obese individuals. This study found that iron absorption in obese women was only two-thirds of that in normal-weight women.

Additionally, the effect of vitamin C, which is a common enhancer of iron absorption, was only one-half of that in normal-weight women. The authors suggested that inflammation in the digestive system may be responsible.


Low levels of physical activity are associated with dysregulation of energy intake and fat mass gain over 1 year.

Lack of physical activity is a well-known risk factor for obesity. This clinical trial supports previous studies, suggesting that sedentary lifestyles cause an imbalance in calorie intake and calories burned.


Appetite and Calorie Intake

No difference in ad libitum energy intake in healthy men and women consuming beverages sweetened with fructose, glucose, or high-fructose corn syrup: a randomized trial.

This randomized controlled trial in healthy adults found that calorie intake was higher in those who consumed sugar-sweetened beverages, compared with aspartame-sweetened beverages.

They also found that the type of sugar did not matter. Drinking beverages sweetened with fructose, glucose or high-fructose corn syrup affected calorie intake similarly.


Metabolic Syndrome

Vitamin D deficiency in non-alcoholic fatty liver disease: The chicken or the egg?

Circulating vitamin D levels are often low in people with non-alcoholic fatty liver disease (NAFLD).

This weight-loss trial in patients with NAFLD found that weight loss increased vitamin D levels, even without vitamin D supplementation. Additionally, liver fat, liver enzymes and metabolic health improved.


Blood Sugar Control and Diabetes

Carbohydrate quality and quantity and risk of type 2 diabetes in US women.

This large, prospective observational study suggests that diets high in starch and low in fiber may increase the risk of type 2 diabetes. Similarly, a high ratio of starch to cereal fiber was associated with an increased risk of type 2 diabetes.


Zinc and Other Metals Deficiencies and Risk of Type 1 Diabetes: An Ecological Study in the High Risk Sardinia Island.

This observational study suggests that micronutrients, such as cobalt, chromium, copper, manganese, nickel and zinc, may protect against type 1 diabetes.


Insulin resistance determines a differential response to changes in dietary fat modification on metabolic syndrome risk factors: the LIPGENE study.

This large, randomized controlled trial in individuals with metabolic syndrome found that those with greater insulin resistance responded differently to dietary changes to the type of fat.

For example, people with greater insulin resistance were more likely to respond negatively when switching over to a diet high in saturated fat. Similarly, they benefited more from replacing saturated fats with monounsaturated fats or omega-3.


Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus.

This meta-analysis of randomized controlled trials showed that psyllium fiber supplementation had beneficial effects on blood sugar control.

Taking psyllium fiber had greater benefits in patients who were being treated for type 2 diabetes, compared to those who were at risk for type 2 diabetes.


Metabolic response to omega-3 fatty acid supplementation in patients with diabetic nephropathy: a randomized, double-blind, placebo-controlled trial.

This randomized controlled trial in patients with diabetic nephropathy found that supplementation with omega-3 fat from flaxseed oil, 1000 mg per day for 12 weeks, reduced insulin levels and improved insulin sensitivity.

Additionally, omega-3 supplementation had beneficial effects on blood lipid levels. Conversely, the study didn‘t detect any improvements in inflammation or oxidative stress.


Heart Health

Vaccenic acid and trans fatty acid isomers from partially hydrogenated oil both adversely affect LDL cholesterol: a double-blind, randomized controlled trial.

Vaccenic acid is the most abundant trans fat naturally found in dairy fat.

This randomized controlled trial showed that vaccenic acid is as bad for LDL-cholesterol levels as industrially produced trans fatty acids, when consumed in equal amounts.


Dietary fat intake and risk of cardiovascular disease and all-cause mortality in a population at high risk of cardiovascular disease.

To reduce the risk of heart disease, improving fat quality is more important than reducing the total intake of dietary fat.

This observational study suggests that eating monounsaturated fats and polyunsaturated fats may protect against heart disease. High intake of saturated fats and trans fatty acids was associated with an increased risk of heart disease.


Effects of tree nuts on blood lipids, apolipoproteins, and blood pressure: systematic review, meta-analysis, and dose-response of 61 controlled intervention trials.

This meta-analysis of controlled trials found that eating tree nuts may have beneficial effects on the blood lipid profile, improving the levels of total cholesterol, LDL-cholesterol, apolipoprotein B and triglycerides.

These results indicate that consuming tree nuts on a regular basis may help prevent heart disease.


The effect of moderate alcohol consumption on biomarkers of inflammation and hemostatic factors in postmenopausal women.

This randomized crossover study in postmenopausal women found that moderate alcohol consumption may reduce inflammation.

Additionally, moderate alcohol consumption improved hemostatic factors, which are substances that mediate blood clotting and have been associated with increased heart disease risk.


Safety and efficacy of cocoa flavanol intake in healthy adults: a randomized, controlled, double-masked trial.

Previous evidence indicates that cocoa flavonoids may improve heart health. This randomized controlled trial in healthy adults suggests that taking cocoa flavonoids, 2000 mg/day for 12 weeks, is well tolerated.

Supplementing with cocoa flavonoids did not have any significant effects on blood pressure or platelet factors, compared with the control groups.


Cancer

The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition.

High coffee intake has been associated with a lower risk of liver cancer.

This observational study suggests that the protective effects of coffee may be due to its beneficial effects on inflammation and liver health.


Are strict vegetarians protected against prostate cancer?

This observational study suggests that vegan diets may lower the risk of prostate cancer.


Effects of Calcium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Colorectal Adenoma Patients: A Randomized Controlled Trial.

Calcium has been associated with a reduced risk of colon cancer. This randomized controlled trial in patients with previous colon cancer tested two different supplementary doses of calcium, 1 g/day and 2 g/day.

The study did not reveal any protective effects of calcium supplementation. Markers for inflammation and oxidative stress were similar between groups.


Brain Function and Mental Health

Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.

Folate is important for normal brain development. This randomized controlled trial suggests that folate supplementation during pregnancy improves cognition in the child.

Conversely, long-chain omega-3 fatty acids from fish oil did not appear to have any significant effects on cognition.


Liver Health

Coffee Consumption Decreases Risks for Hepatic Fibrosis and Cirrhosis: A Meta-Analysis.

This meta-analysis of human trials shows that regular coffee consumption may reduce the risk of liver diseases, such as cirrhosis and hepatic fibrosis.


Bone Health

Dietary acid load in early life and bone health in childhood: the Generation R Study.

Some scientists claim that acid-base balance in early life may affect bone mineral density in later life.

This prospective observational study in children does not support this idea. It suggests that dietary acid load in infancy is not associated with bone health in later childhood.


Cross-sectional and prospective associations between dietary and plasma vitamin C, heel bone ultrasound, and fracture risk in men and women in the European Prospective Investigation into Cancer in Norfolk cohort.

Adequate amounts of vitamin C may help prevent osteoporosis. This observational study found that higher vitamin C intake was significantly associated with greater bone mineral density in both men and women.

Additionally, circulating vitamin C levels were associated with decreased risk of fractures, but only in men.


Fertility and Pregnancy

Intake of carbohydrates during pregnancy in obese women is associated with fat mass in the newborn offspring.

This observational study indicates that if pregnant, obese women eat high amounts of carbs in late pregnancy, their children are more likely to be fat when they are born.


Short-term effects of a hypocaloric diet with low glycemic index and low glycemic load on body adiposity, metabolic variables, ghrelin, leptin, and pregnancy rate in overweight and obese infertile women: a randomized controlled trial.

This 12-week, randomized controlled trial in overweight or obese infertile women found that weight loss significantly improved fertility and increased pregnancy rate. It also reduced body mass index, body fat percentage and leptin levels.


Infant Nutrition

Neuroimaging identifies increased manganese deposition in infants receiving parenteral nutrition.Manganese is a trace element that is essential for normal growth and development. However, it is neurotoxic in high amounts.

This prospective observational study indicates that a high dietary intake of manganese in infants may cause manganese to accumulate in the brain. The health implications are unclear.


Healthy Aging

Plasma vitamin D biomarkers and leukocyte telomere length in men.

Telomeres are protective structures at the ends of DNA strands. Their lengths shorten with age. This shortening has been implicated as one of the causes of aging.

This cross-sectional observational study in men found no significant association between vitamin D levels and telomere length.

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